Human therapeutic targets and modulators thereof

• Main Authors: BIGGINS JOHN BAXTER, BOWMAN BRIAN ROGER, VERDINE GREGORY L
• Format: Patent
• Language: Chinese; English
• Published: 11.09.2020
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PHYSICS; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

Among other things, the present disclosure provides technologies for efficient and effective identification of ETaGs, for example, from fungi genomes. In some embodiments, provided technologies are particularly useful for identifying mammalian targets of biosynthetic products of fungi. In some embodiments, provided technologies are particularly useful for identifying and/or prioritizing human targets for drug development. In some embodiments, provided technologies are particularly useful for developing modulators for human targets based on biosynthetic products of fungi. 本公开内容尤其提供了用于例如从真菌基因组中高效且有效地鉴定ETaG的技术。在一些实施方案中，所提供的技术可特别地用于鉴定真菌生物合成产物的哺乳动物靶标。在一些实施方案中，所提供的技术可特别地用于鉴定用于药物开发的人靶标和/或对其进行优先排序。在一些实施方案中，所提供的技术可特别地用于基于真菌的生物合成产物来开发用于人靶标的调节剂。