Composition for improving expression of cell tight junction protein, and preparation method and application of composition

• Main Authors: LIANG LIXIAN, JIANG ZHIHONG, LIU LIANG, XIAO WENLUAN
• Format: Patent
• Language: Chinese; English
• Published: 04.09.2020
• Subjects: FODDER; FOODS OR FOODSTUFFS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES

The invention belongs to the field of medicines, and particularly discloses a composition for improving the expression of a cell tight junction protein. The composition comprises at least two of flossophorae extracts, lonicerae japonica flos extracts or fructus gardenia extracts. The composition can effectively improve the expression of the tight junction protein in the intestinal tract of a host, accelerate N cadherin to be converted to E cadherin, up-regulate the level of the E cadherin, down-regulate the level of the E cadherin, improves intestinal epithelial integrity, further perform ananti-cancer and anti-inflammation function, and maintain the intestinal tract health of the host. The extracts contained in the composition derive from Chinese medicinal materials with high safety, sothat the composition has a small side effect and high safety. The invention also discloses a preparation method for the composition, and the composition is applied to medicines or feed. 本发明属于医药领域，具体公开了一种提高细胞紧密连接蛋白表达的组合物，所述组合物包