METHOD FOR INACTIVATING ZIKA VIRUS AND RELATED METHODS

• Main Authors: SATOU TATSUKI, ADACHI SATOSHI, RAO RAMAN, LYONS MARK, MISAKI MASAFUMI, DEAN HANSI, MARKS JACKIE, GIEBLER HOLLI, GIFFORD JAMIE, OGASAWARA NAO, LIVENGOOD JILL A, SHINTANI ASAE
• Format: Patent
• Language: Chinese; English
• Published: 28.08.2020
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The present disclosure relates to methods for inactivating a Zika virus which can be used in vaccines and immunogenic compositions. The present disclosure also relates to a method for determining thecompleteness of inactivation of an arbovirus preparation and to a method for determining the residual formaldehyde content in a pharmaceutical composition comprising an inactivated virus. 本公开涉及用于将寨卡病毒灭活的方法，所述寨卡病毒可用于疫苗和免疫原性组合物中。本公开还涉及一种用于确定虫媒病毒制剂的灭活完全性的方法和一种用于确定包含灭活病毒的药物组合物中的残余甲醛含量的方法。