Cy5-650 and application of Cy5-650 in preparation of anti-tumor drugs

• Main Authors: CHEN MINGLIANG, LIU WENQING, JIANG XIAOMEI, ZHANG LEI, WANG QUN, JIA SHUANGSHUANG, SHI XIAO, JIA RUOHAN, LIU FANGYAN, JIE RU, CHANG HAIBO, TANG KUN, LIU XUQIAN
• Format: Patent
• Language: Chinese; English
• Published: 25.08.2020
• Subjects: ADHESIVES; CHEMISTRY; DYES; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; LAKES; MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FORELSEWHERE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MISCELLANEOUS APPLICATIONS OF MATERIALS; MISCELLANEOUS COMPOSITIONS; MORDANTS; NATURAL RESINS; ORGANIC CHEMISTRY; ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES; PAINTS; POLISHES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention belongs to the technical field of chemical medicine, and relates to application of 1, 5-bis [N-(3, 5-bis (2-(2-methoxyethoxy) ethoxy) ethoxy) benzyl-2, 3, 3-trimethyl-5-sulfo-3H-indole]-3-(4-pyridine) penta-carbonyanine bromide dye (Cy5-650 for short) in preparation of anti-tumor drugs. MTT results show that the Cy5-650 can significantly inhibit the cell viability of the colorectal cancer cell line DLD-1. Animal experiment results show that Cy5-650 significantly inhibits the growth of human colorectal cancer cell line DLD-1 BALB/C nude mouse subcutaneous tumor-bearing, and can beused for preparing anti-tumor drugs. The compound Cy5-650 disclosed by the invention is developed as a novel anti-tumor drug or an auxiliary component thereof, has a remarkable tumor inhibition effect; and the novel treatment way and means are provided for treating and curing tumors. 本发明属于化工医药技术领域，涉及1,5-二[N-(3,5-二(2-(2-甲氧乙氧基)乙氧基)乙氧基)苄基-2,3,3-三甲基-5-磺酸基-3H-吲哚]-3-(4-吡啶)五碳菁溴化盐染料(简称为Cy5-650)在制备抗肿瘤药物中的应用。MTT结果显示：Cy5-650能显著抑制结直