Claudin6 antibodies and methods of treating cancer

• Main Authors: CONKLIN DYLAN, O'BRIEN NEIL, VON EUW ERIKA, SLAMON DENNIS, PALAZZOLO MIKE
• Format: Patent
• Language: Chinese; English
• Published: 21.08.2020
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present disclosure provides antigen-binding proteins which bind to Claudin-6 (CLDN6). In various aspects, the antigen-binding proteins bind to Extracellular Loop 2 (EL2) of the extracellular domain of CLDN6. Related polypeptides, nucleic acids, vectors, host cells, and conjugates are further provided herein. Kits and pharmaceutical compositions comprising such entities are moreover provided. Also provided are methods of making an antigen-binding protein and methods of treating a subject having cancer. 本公开提供了与紧密连接蛋白-6(CLDN6)结合的抗原结合蛋白。在各个方面，所述抗原结合蛋白与CLDN6的胞外结构域的胞外环2(EL2)结合。本文还提供了相关多肽、核酸、载体、宿主细胞和缀合物。此外，提供了包含此类实体的试剂盒和药物组合物。还提供了制备抗原结合蛋白的方法和治疗患有癌症的受试者的方法。