Carbidopa and L-dopa prodrugs and their use to treat Parkinson's disease

• Main Authors: HENRY RODGER F, ENRIGHT BRIAN P, KRABBE SCOTT W, MILLER CHRISTOPHER P, HO RAIMUNDO, LAO YANBIN, LOU XIAOCHUN, STAMBULI JAMES, CARDINAL-DAVID BENOIT, STELLA VALENTINO J, HUANG YE, HUTERS ALEXANDER D, MAYER PETER T, KYM PHILIP R, CHAN VINCENT S, MACKEY SEAN E, MATULENKO MARK A, ZHANG GEOFF G, DEMPAH KASSIBLA E, VOIGHT ERIC A, KLIX RUSSELL C, WANG ZHI
• Format: Patent
• Language: Chinese; English
• Published: 28.07.2020
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present disclosure relates to carbidopa and L-dopa prodrugs and their use to treat Parkinson's disease. The present disclosure relates to (a) carbidopa prodrugs, (b) pharmaceutical combinations and compositions comprising a carbidopa prodrug and/or an L-dopa prodrug, and (c) methods of treating Parkinson's disease and associated conditions comprising administering a carbidopa prodrug and an L-dopa prodrug to a subject with Parkinson's disease. 本发明涉及卡比多巴和左旋多巴前药及它们治疗帕金森病的用途。本公开涉及(a)卡比多巴前药，(b)包含卡比多巴前药和/或左旋多巴前药的药物组合产品和组合物，和(c)治疗帕金森病和相关病症的方法，所述方法包括给予患有帕金森病的对象卡比多巴前药和左旋多巴前药。