Preparation method of high-all-trans carotenoid microcapsule

• Main Authors: ZHANG TAO, LI LI, JIANG TIANYUE, GAO HONGKUN, LIU YINGRUI, LYU YINGDONG
• Format: Patent
• Language: Chinese; English
• Published: 17.07.2020
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention provides a preparation method of a high-all-trans carotenoid microcapsule. The method comprises the following steps: 1) grinding carotenoid crystals with an all-trans isomer content of more than 96 percent, porous starch, vegetable oil and an antioxidant into carotenoid oil suspension through a ball mill; 2) mixing a protective colloid, carbohydrates and deionized water to obtain a protective colloid aqueous solution; 3) slowly adding the carotenoid oil suspension into the protective colloid aqueous solution, adjusting pH value, performing shearing at a high speed to obtain an oil-in-water primary emulsion of the carotenoid, and performing homogenization to obtain a carotenoid emulsion; and 4) spray drying the emulsion to obtain the carotenoid microcapsule. The method has theadvantages that: the porous starch is used as a core material carrier, oxidation of the carotenoid is effectively avoided, an all-trans structure of the carotenoid is ensured, the pH value of the emulsion is adjusted in the