WATER-SOLUBLE COMPOUNDS WITH AGGREGATION-INDUCED EMISSION CHARACTERISTICS

• Main Authors: TANG BENZHONG, WANG DONG
• Format: Patent
• Language: Chinese; English
• Published: 09.06.2020
• Subjects: ADHESIVES; CHEMISTRY; COMPOSITIONS BASED THEREON; DYES; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS; MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FORELSEWHERE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MISCELLANEOUS APPLICATIONS OF MATERIALS; MISCELLANEOUS COMPOSITIONS; NATURAL RESINS; ORGANIC CHEMISTRY; ORGANIC MACROMOLECULAR COMPOUNDS; PAINTS; POLISHES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; THEIR PREPARATION OR CHEMICAL WORKING-UP

The present subject matter relates to water-soluble, fluorescent compounds that have aggregation-induced emission (AIE) characteristics and exhibit near infrared (NIR) absorption. The compounds can beutilized as plasma-membrane specific bio-probes in cell imaging through a wash-free and fast staining procedure. In addition, the compounds can efficiently generate reactive oxygen species (ROS) in vivo when irradiated with visible light. As such, the compounds can be effective in killing cancer cells through image-guided, photodynamic therapy (PDT) processes. 本主题涉及具有聚集诱导发光(AIE)特性，并呈现出近红外(NIR)吸收的水溶性荧光化合物。这些化合物可以通过免洗和快速染色程序在细胞成像中用作质膜特异性生物探针。此外，当用可见光照射时，这些化合物可以在体内有效地生成活性氧簇(ROS)。因此，这些化合物可以通过图像引导的光动力疗法(PDT)过程有效地杀死癌细胞。