ASSESSMENT OF NOTCH CELLULAR SIGNALING PATHWAY ACTIVITY USING MATHEMATICAL MODELLING OF TARGET GENE EXPRESSION

• Main Authors: VERHAEGH WILHELMUS FRANCISCUS JOHANNES, VAN DE STOLPE ANJA, HOLTZER LAURENTIUS HENRICUS FRANCISCUS MARIA
• Format: Patent
• Language: Chinese; English
• Published: 19.05.2020
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PHYSICS; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPIRITS; TESTING; VINEGAR; WINE

The present invention relates to a computer-implemented method for inferring activity of a Notch cellular signaling pathway in a subject based on expression levels of three or more target genes of theNotch cellular signaling pathway measured in a sample of the subject. The present invention further relates to an apparatus, to a non-transitory storage medium, and to a computer program for inferring activity of a Notch cellular signaling pathway in a subject. The present invention further relates to a kit for measuring expression levels of three or more target genes of the Notch cellular signaling pathway in a sample of a subject, to a kit for inferring activity of a Notch cellular signaling pathway in a subject, and to the use of such kits in performing the method. 本发明涉及一种计算机执行方法，其基于在对象样品中测量的Notch细胞信号传导途径的三个或更多个靶基因的表达水平来推测对象中Notch细胞信号传导途径的活性。本发明还涉及用于推测对象中Notch细胞信号传导途径的活性的设备，非暂时性存储介质和计算机程序。本发明进一步涉及用于测量对象样品中Notch细胞信号传导途径的三个或更多个靶基因的表达水平的试剂盒，用于推测对象中Notch细胞信号传导途径的活性的试剂盒以及这种试剂盒在实施所述方法中的应用。