KRAS G12C inhibitors and methods of using the same

Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, andlung cancers. 本文提供KRAS G12C抑制剂、其组合物及其使用方法。这些抑制剂可用于治疗多种病症，包括胰腺癌、结肠直肠癌及肺癌。...

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Main Authors NISHIMURA NOBUKO, WURZ RYAN PAUL, CEE VICTOR J, BOOKER SHON, SHIN YOUNGSOOK, LANMAN BRIAN ALAN, ALLEN JENNIFER REBECCA, KOPECKY DAVID JOHN, TAMAYO NURIA A, ALLEN JOHN GORDON, LIU LONGBIN, CHEN JIAN, NGUYEN THOMAS T, REED ANTHONY B, LOPEZ PATRICIA
Format Patent
LanguageChinese
English
Published 10.04.2020
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, andlung cancers. 本文提供KRAS G12C抑制剂、其组合物及其使用方法。这些抑制剂可用于治疗多种病症，包括胰腺癌、结肠直肠癌及肺癌。
Bibliography:Application Number: CN201880047910