Pharmaceutical composition for treating hemangioma and vascular malformation sclerosis and preparation method and application thereof

• Main Authors: YANG XI, SUN YI, CHEN HUI, LIN XIAOXI
• Format: Patent
• Language: Chinese; English
• Published: 03.04.2020
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses a pharmaceutical composition for treating hemangioma or vascular malformation sclerosis. The pharmaceutical composition at least comprises bleomycin and a foam hardener. The invention further discloses a preparation method and application of the pharmaceutical composition. By using the pharmaceutical composition disclosed by the invention, the retention time of bleomycin ina local focus can be prolonged, and the contact area between bleomycin and a lesion vessel is increased. The embolization efficiency is improved, and a better treatment effect is achieved. Accordingto the composition disclosed by the invention, reduction of single dosage of bleomycin is realized, so that bleomycin plays a stronger treatment role within the limit of the lifetime dosage thereof. 本发明公开了一种用于血管瘤或脉管畸形硬化治疗的药物组合物，所述药物组合物至少包括博来霉素和泡沫硬化剂。本发明还公开了该药物组合物的制备方法和应用。使用本发明的药物组合物能提高博来霉素在局部病灶的停留时间，增加其与病变脉管的接触面积，从而提高栓塞效率，达到较好治疗效果。本发明的组合物实现了博来霉素单次使用剂量的降低，进而使博来霉素在其终生剂量限制内发挥更强的治疗作用。