PASSIVE ANTIBODY DEPENDENT CELL-MEDIATED ACTIVATION

• Main Authors: DAI HONGSHENG, YU JIANHUA, CALIGIURI MICHAEL
• Format: Patent
• Language: Chinese; English
• Published: 03.12.2019
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

Disclosed herein are methods, reagents, and pharmaceutical compositions for modulating immune effector cell activation that does not requirean antigen-specific antibody. The IgG Fc region is shown herein to contain both a domain that binds an FcgammaR on immune effector cells and a non-overlapping region or domain that can bind Fc binding proteins on target cells, and that it is capable of bridging immune effector cells and target cells expressing Fc binding proteins without use of the antigen-binding region (Fab) of the antibody. Therefore, also disclosed are methods of enhancing or inhibiting passive ADCC in subjects. 本文公开了用于调节免疫效应细胞活化的方法、试剂和药物组合物，其不需要抗原特异性抗体。本文显示了IgG Fc区包含结合免疫效应细胞上的FcγR的结构域和能够结合靶细胞上的Fc结合蛋白的非重叠区域或结构域，并且其能够桥接免疫效应细胞和表达Fc结合蛋白的靶细胞而不使用抗体的抗原结合区(Fab)。因此，还公开了增强或抑制受试者中的被动ADCC的方法。