Amphotericin B derivatives with improved therapeutic index

• Main Authors: PALYAM NAGARJUNA, KNAPP DAVID M, STRUBLE JUSTIN, DAVIS STEPHEN, DAILEY IAN, BURKE MARTIN D, GRAY KAITLYN C, UNO BRICE E, WANG PULIN
• Format: Patent
• Language: Chinese; English
• Published: 05.11.2019
• Subjects: CHEMISTRY; DERIVATIVES THEREOF; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SUGARS

Provided are certain derivatives of amphotericin B (AmB) characterized by reduced toxicity and retained anti-fungal activity. Certain of the derivatives are C16 urea derivatives of AmB. Certain of thederivatives are C3, C5, C8, C9, C11, C13, or C15 deoxy derivatives of AmB. Certain of the derivative...