CHIMERIC ANTIGEN RECEPTOR EFFECTOR CELL SWITCHES WITH HUMANIZED TARGETING MOIETIES AND/OR OPTIMIZED CHIMERIC ANTIGEN RECEPTOR INTERACTING DOMAINS AND USES THEREOF

The present disclosure provides compositions, methods, kits, and platforms for selectively activating and deactivating chimeric receptor effector cells using humanized chimeric receptor effector cell switches that comprise a humanized targeting moiety that binds CD19 on a target cell and a chimeric...

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Main Authors HAMPTON ERIC, VIAUD SOPHIE, WRIGHT TIMOTHY, LABORDA EDUARDO, RODGERS DAVID, YOUNG TRAVIS S, SCHULTZ PETER G, KHIALEEVA ELVIRA, PRESTA LEONARD
Format Patent
LanguageChinese
English
Published 20.09.2019
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