Localized modulation of tissues and cells to enhance therapeutic effects including renal denervation

• Main Author: SEWARD KIRK P
• Format: Patent
• Language: Chinese; English
• Published: 06.09.2019
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Pharmaceutical preparations, compositions, systems, and devices including medical devices and diagnostic or therapeutic agents, and methods to treat disease by modification of local tissue environmentto modulate the therapeutic index of locally or systemically delivered therapeutic or diagnostic agents. Improved ability to reduce sympathetic nerve activity in the adventitia and perivascular tissues around arteries and veins in the body. Modulation of the local tissue environment around an artery to enable more effective denervation with or without a therapeutic agent. Modulation may include adjustment of the pH of the tissue. 本发明提供了通过改变局部组织环境来调节局部或全身递送治疗或诊断剂的治疗指数而治疗疾病的药物制剂、组合物、系统和装置(包括医疗器械和诊断或治疗剂)，以及方法。本发明还提供了减少体内动脉和静脉周围的外膜和血管周围组织中的交感神经活动力的改进的能力。本发明还提供了动脉周围的局部组织环境的调节以使得能够使用或者不使用治疗剂更有效地去神经支配。调节可以包括调节组织的pH值。