PYRROLO-AROMATIC HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR, AND MEDICAL USE THEREOF

• Main Authors: TIAN WEIXUE, YIN HUIJUN, ZONG LIBIN, YANG YAN, ZHENG LI, YAN XU, DOU HAOSHUAI
• Format: Patent
• Language: Chinese; English
• Published: 30.07.2019
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to a pyrrolo-aromatic heterocyclic compound, a preparation method therefor, and medical use thereof. Particularly, the present invention relates to a compound representedby formula I, a preparation method therefor, a pharmaceutical composition comprising the compound, and use of the compound as a BTK kinase inhibitor. The compound and the pharmaceutical composition comprising same can be used for treating diseases associated with BTK kinase activity, such as inflammations, autoimmune disorders, and cancers. The definition of each substituent in formula I is the same as that in the description. 本发明涉及吡咯并芳杂环类化合物及其制备方法和医药用途。特别地，本发明涉及通式I所示的化合物、其制备方法及含有该化合物的药物组合物，及其作为BTK激酶抑制剂的用途，该化合物及其含有该化合物的药物组合物可以用于治疗与BTK激酶活性相关的疾病，例如炎症、自身免疫性病症、癌症等。其中通式I中的各取代基的定义与说明书中的定义相同。