Polypyridine ruthenium complex and preparing method and application thereof

• Main Authors: ZHOU QIANXIONG, CHENG XUEXIN, RENA BOERHAN, WANG XUESONG
• Format: Patent
• Language: Chinese; English
• Published: 05.07.2019
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses a polypyridine ruthenium complex. The complex has the structure shown in the formula I (the formula I can be seen in the description), wherein X- represents monovalent anions for balancing charges. The complex has high phototoxicity and low dark toxicity, can be well used for preparing photoactivation anti-tumor medicines, and can overcome the defect of the great toxic andside effects of traditional chemotherapy medicines. The invention further discloses a preparing method and application of the polypyridine ruthenium complex. 本发明公开了一种多吡啶钌配合物，该配合物具有如下式I所述的结构：其中，X表示平衡电荷的一价阴离子。该配合物具有高光毒性、低暗毒性，可较好的用于制备光活化抗肿瘤药物中，能克服传统化疗药物毒副作用大的缺陷。本发明还公开了该多吡啶钌配合物的制备方法和应用。