Preparation method of multilayer graphene sensing biochip

• Main Authors: ZOU HONGTAO, YANG ZAIBO, DAI XUEXIN, HUANG DENA, PENG KAIMEI, YANG YAN, MAO HAILI
• Format: Patent
• Language: Chinese; English
• Published: 11.06.2019
• Subjects: CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; PHYSICS; TESTING; TRANSPORTING

The invention discloses a preparation method of a multilayer graphene sensing biochip. The chip comprises a support layer, a click modification layer, multiple layers of graphene and a fixed modification layer; the click modification layer is covalently anchored on the support layer; the graphene is covalently bonded on the click modification layer through click chemistry; the multiple layers of the graphene are covalently combined through the click chemistry; and the fixed modification layer is covalently bonded on the graphene. The multilayer graphene sensing biochip provided by the invention has the advantages of being stable in structure and high in sensitivity. 本发明公开了一种多层石墨烯传感生物芯片的制备方法。该芯片包括支撑层、点击化修饰层、多层石墨烯和固定修饰层；所述点击化修饰层共价锚定于支撑层上；所述石墨烯通过点击化学共价结合于点击修饰层上；所述多层石墨烯通过点击化学共价相结合；所述固定修饰层通过共价结合于石墨烯上。本发明提供的多层石墨烯传感生物芯片具有结构稳定及灵敏度高的优点。