Method for promoting corticospinal tract regeneration to repair spinal cord injury by optogenetic stimulation to activate large-scale cortex

• Main Authors: ZENG YUANSHAN, WANG JUNHUA, WEI QINGSHUAI, ZENG XIANG, MA YUANHUAN
• Format: Patent
• Language: Chinese; English
• Published: 03.05.2019
• Subjects: ELECTROTHERAPY; HUMAN NECESSITIES; HYGIENE; MAGNETOTHERAPY; MEDICAL OR VETERINARY SCIENCE; RADIATION THERAPY; ULTRASOUND THERAPY

The present invention discloses a method for promoting corticospinal tract regeneration to repair spinal cord injury by optogenetic stimulation to activate large-scale cortex. LED lights are used as alight source of light stimulation to enlarge illumination area, thereby activating the cortex in a large area. A waveform generator is applied to accurately control intensity, frequency and wavinesswidth of the LED lights to achieve desired light stimulation parameters. The method conducts the large-scale specific optogenetic stimulation for neurons without damaging brain tissue, avoids influence on glial cells, thus specifically enhances electrical activity of the neurons in large-area brain regions, promotes axonal regeneration to improve neuronal functions after the spinal cord injury andconducts wide-range specific activation of a fifth layer of pyramidal neurons in the cortex to promote the regeneration of a large number of corticospinal tracts after the spinal cord injury. 一种光遗传学刺激大范围大脑皮层促进皮质脊髓束再生以修复脊髓损伤的方法