Application of SNase in preparation of medicament for treating inflammatory bowel disease

• Main Authors: DONG WANFA, ZHANG TINGTING, WU JIE
• Format: Patent
• Language: Chinese; English
• Published: 12.04.2019
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; ENZYMES; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The invention relates to the application of staphylococcal nuclease (SNase) in preparation of a medicament for preventing or treating inflammatory bowel disease. The object of the present invention isto provide a novel use of SNase in action of resisting inflammatory bowel disease. Results show that SNase can significantly alleviate colonic inflammation in C57BL/6J mice, can better control the body weight, colon length, fecal occult blood and inflammatory infiltration of the C57BL/6J mice, and significantly improve the survival rate of the C57BL/6J mice. Therefore, the SNase can significantlyalleviate intestinal inflammation in the C57BL/6J mice, and can be used for development of medicaments for prevention and treatment of inflammatory bowel diseases. 本发明涉及葡萄球菌核酸酶（staphylococcal nuclease,SNase)在制备预防或治疗炎症性肠病药物中的应用。本发明的目的是提供SNase在抗炎症性肠病作用中的新用途。结果显示SNase可以明显缓解C57BL/6J小鼠的结肠炎症，能够较好地控制C57BL/6J小鼠的体重，结肠长度，粪便潜血以及炎症浸润等，并且显著提高C57BL/6J小鼠的生存率。由此可知，SNase可以明显缓解C57BL/6J小鼠肠道炎症，可用于预防和治疗炎症性肠病药物的开发。