Application of SNase in preparation of medicament for treating inflammatory bowel disease

The invention relates to the application of staphylococcal nuclease (SNase) in preparation of a medicament for preventing or treating inflammatory bowel disease. The object of the present invention isto provide a novel use of SNase in action of resisting inflammatory bowel disease. Results show that...

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Bibliographic Details
Main Authors DONG WANFA, ZHANG TINGTING, WU JIE
Format Patent
LanguageChinese
English
Published 12.04.2019
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Summary:The invention relates to the application of staphylococcal nuclease (SNase) in preparation of a medicament for preventing or treating inflammatory bowel disease. The object of the present invention isto provide a novel use of SNase in action of resisting inflammatory bowel disease. Results show that SNase can significantly alleviate colonic inflammation in C57BL/6J mice, can better control the body weight, colon length, fecal occult blood and inflammatory infiltration of the C57BL/6J mice, and significantly improve the survival rate of the C57BL/6J mice. Therefore, the SNase can significantlyalleviate intestinal inflammation in the C57BL/6J mice, and can be used for development of medicaments for prevention and treatment of inflammatory bowel diseases. 本发明涉及葡萄球菌核酸酶(staphylococcal nuclease,SNase)在制备预防或治疗炎症性肠病药物中的应用。本发明的目的是提供SNase在抗炎症性肠病作用中的新用途。结果显示SNase可以明显缓解C57BL/6J小鼠的结肠炎症,能够较好地控制C57BL/6J小鼠的体重,结肠长度,粪便潜血以及炎症浸润等,并且显著提高C57BL/6J小鼠的生存率。由此可知,SNase可以明显缓解C57BL/6J小鼠肠道炎症,可用于预防和治疗炎症性肠病药物的开发。
Bibliography:Application Number: CN2019173368