Core-shell structure cellulose-based probiotic microcapsule and preparation method thereof

• Main Authors: HUANG FENGHONG, LUAN QIAN, ZHANG HAO, BAO YUPING, TANG HU
• Format: Patent
• Language: Chinese; English
• Published: 29.03.2019
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses a core-shell structure cellulose-based probiotic microcapsule which is prepared by preparing a core from a mixture of a cellulose nanofiber and probiotics under the crosslinking action of Ca<2+>, preparing a coating from water-soluble chitosan and sodium alginate and by implementing a layer-by-layer self-assembling technique. The microcapsule disclosed by the invention hasan average particle size of 2-5mm, and is of a remarkable core-shell structure, probiotics are mainly distributed in the core of the microcapsule, amount controllable loading of the probiotics is achieved, good pH response properties and probiotic slow-release properties can be achieved, and effective protection on the probiotic and target release in intestinal tracts are achieved. 本发明公开了种核壳结构纤维素基益生菌微胶囊。该微胶囊由纤维素纳米纤维与益生菌的混合物在Ca交联作用下制备成内核，再以水溶性壳聚糖和海藻酸钠为涂层，利用层层自组装技术制备得到核壳结构纤维素基益生菌微胶囊。本发明制备得到的微胶囊的平均粒径为2~5mm，呈现出明显的核壳结构，且益生菌主要分布在微胶囊内核中，实现益生菌的可控量负载，且具有良好的pH响应性能与益生菌缓释性能，实现对益生菌的有效保护与肠道靶向释放。