[mu]-opiate receptor stimulant and preparation method and application in medicine field

• Main Authors: XU XIN, LIU QIANG, LI DONGSHENG, GE JIAN, ZHANG LINLI, SU JING, WANG YIJIN, ZHANG LIMING, ZHANG TIAN, LIU LEI, JIANG QINGYUN, GUO FENGYING, SONG JINQIAN, LI YUNFEI
• Format: Patent
• Language: Chinese; English
• Published: 26.03.2019
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention provides a [mu]-opiate receptor stimulant and a preparation method and an application in medicine field and belongs to the field of medicinal chemistry. The selectivity of the [mu]-opiate receptor stimulant to a G protein signal channel is improved obviously, so that the [mu]-opiate receptor stimulant not only shows excellent drug action, but also is improved obvious in safety. 本发明提供类μ-阿片受体激动剂及其制备方法和在医药领域的应用，属于药物化学领域。所述μ-阿片受体激动剂对G蛋白信号通路的选择性显著提高，不仅能表现出优异的药效作用，而且在安全性方面也得到显著改善。