Gene nanoprobe for targeted lung cancer treatment as well as preparation method and application thereof

• Main Authors: ZHANG SHUSHENG, YUAN DANDAN, LI XUEMEI, CUI BINGJIE, DING LAIRONG, ZHANG JIAYU
• Format: Patent
• Language: Chinese; English
• Published: 06.11.2018
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The invention relates to a gene nanoprobe for targeted lung cancer treatment as well as a preparation method and application thereof, and belongs to the technical field of biochemical nano materials.The gene nanoprobe for the targeted lung cancer treatment comprises an RNA nano hydrogel and DOX and/or TMPyP4 loaded on the RNA nano hydrogel; the RNA nano hydrogel comprises a DNA self-assembled single chain, a cyclization DNA template and a targeted aptamer. The gene nanoprobe has a strong specific recognition ability, precise targeting, small toxic and side effects, high killing and injuring intensity against lung cancer cells, good therapeutic effect, and great potential in the application of the lung cancer treatment. 本发明涉及种用于靶向肺癌治疗的基因纳米探针及其制备方法和应用，属于生物化学纳米材料技术领域。本发明提供的用于靶向肺癌治疗的基因纳米探针包括RNA纳米水凝胶和负载在所述RNA纳米水凝胶上的DOX和/或TMPyP4；所述RNA纳米水凝胶包括DNA自组装单链、成环DNA模板和靶向适配体。本发明所述基因纳米探针特异性识别能力强，靶向精准，毒副作用小，对肺癌细胞的杀伤强度大，治疗效果好，在肺癌治疗的应用中具有极大的潜力。