SHIP1 modulators and methods related thereto

• Main Authors: RAYMOND JEFFERY R, BOGUCKI DAVID, MACRURY THOMAS B, HARWIG CURTIS, KHLEBNIKOV VLADIMIR, SHAN RUDONG, MACKENZIE LYOYD F, PETTIGREW JEREMY D
• Format: Patent
• Language: Chinese; English
• Published: 06.11.2018
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Compounds of formula (I): [Formula should be inserted here]; where [Formula should be inserted here], n, R1, R4a, R4b, R5, R7 and R8 are defined herein, or pharmaceutically acceptable salts thereof, are described herein. The disclosed compounds have activity as SHIP1 modulators, and thus may be used to treat any of a variety of diseases, disorders or conditions that would benefit from SHIP1 modulation. Compositions comprising a compound of formula (I) in combination with a pharmaceutically acceptable carrier or diluent are also disclosed, as are methods of SHIP1 modulation by administration ofsuch compounds to an animal in need thereof. 本文描述了通式(I)的化合物或其药物可接受的盐：其中n、R、R、R、R、R和R在本文定义。公开的化合物具有作为SHIP1调节剂的活性，因此可用于治疗得益于SHIP1调节的多种疾病、病症或疾病状态中的任种。还公开了包含通式(I)的化合物结合药物可接受的载体或稀释剂的组合物以及通过给予需要其的动物这类化合物的SHIP1调节的方法。