Preparation method for ozanimod and intermediate thereof

The invention provides a preparation method for ozanimod and an intermediate thereof. The preparation method comprises the following steps: taking 2,3-dihydro-4-cyano-1-indanone as a raw material, andpreparing a compound III through a proper method; adopting a protecting agent to protect amido and h...

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Bibliographic Details
Main Authors XIONG ZHIGANG, ZHANG XINI, ZHONG JIAN, ZHOU TAO
Format Patent
LanguageChinese
English
Published 02.11.2018
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention provides a preparation method for ozanimod and an intermediate thereof. The preparation method comprises the following steps: taking 2,3-dihydro-4-cyano-1-indanone as a raw material, andpreparing a compound III through a proper method; adopting a protecting agent to protect amido and hydroxyl of the compound III, thereby preparing a compound IV; performing salt treatment on the compound IV to prepare a compound V; performing ring-closure reaction on the compound V and a compound VI to prepare a compound VII; and performing deprotection on the compound VII to prepare ozanimod. Compared with the conventional method, the preparation method reduces reaction steps, increases the total yield, and the prepared products are high in quality; and the reaction conditions are gentle, dangerous operation conditions are avoided, application of highly toxic reagents and expensive chemical reagents is avoided, the safety problem in the conventional method is solved, and the cost is reduced, and the preparation
Bibliography:Application Number: CN201710267498