TREATMENT OF TUMORS INCORPORATING MUTANT ISOCITRATE DEHYDROGENASE

• Main Authors: SI YAGUANG, KEENAN MARIE C
• Format: Patent
• Language: Chinese; English
• Published: 23.10.2018
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present invention provides diagnostic and prognostic methods for predicting the effectiveness of treatment of a cancer patient with a DHODH inhibitor or an antimetabolite. Methods are provided forpredicting the sensitivity of tumor cell growth to inhibition by a DHODH inhibitor or an antimetabolite, comprising assessing whether the tumor cell comprises a mutant IDH gene or protein whereby cells that comprise a mutant IDH gene or protein are sensitive to inhibition by DHODH inhibitors and antimetabolites. 本发明提供用于预测用DHODH抑制剂或抗代谢物治疗癌症患者的有效性的诊断和预后方法。提供了用于预测肿瘤细胞生长对DHODH抑制剂或抗代谢物引起的抑制的敏感性的方法，包括评估肿瘤细胞是否包含突变型IDH基因或蛋白，从而包含该突变型IDH基因或蛋白的细胞对DHODH抑制剂和抗代谢物的引起的抑制是敏感的。