TREATING PANCREATIC CANCER AND NON-SMALL CELL LUNG CANCER WITH ATR INHIBITORS

• Main Authors: POLAR JOHN ROBERT, REAPER PHILIP MICHAEL
• Format: Patent
• Language: Chinese; English
• Published: 31.08.2018
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

This invention relates to methods and compositions for treating pancreatic cancer. More specifically, this invention relates to treating pancreatic cancer with certain ATR inhibitors in combination with gemcitabine and/or radiation therapy. This invention also relates to methods and compositions for treating non- small cell lung cancer. More specifically, this invention relates to treating non-small cell lung cancer with an ATR inhibitor in combination with cisplatin or carboplatin, etoposide, and ionizing radiation. 本发明涉及用于治疗胰腺癌的方法和组合物。更具体地讲，本发明涉及通过某些ATR抑制剂与吉西他滨和/或放射疗法联用来治疗胰腺癌。本发明还涉及用于治疗非小细胞肺癌的方法和组合物。更具体地讲，本发明涉及通过ATR抑制剂与顺铂或卡铂、依托泊苷和电离辐射联用来治疗非小细胞肺癌。