Purification process of vitamin C glucoside

• Main Authors: XIANG MAOGONG, SUN YUNXING, WANG HAIQUAN, SHEN JIAQIU, WANG PENGTIAN, LI WENYUAN, ZHAO GUIJI, ZHANG JIANYONG, WANG XINZHI, WANG BIN
• Format: Patent
• Language: Chinese; English
• Published: 24.08.2018
• Subjects: CHEMISTRY; DERIVATIVES THEREOF; METALLURGY; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; SUGARS

The invention discloses a purification process of vitamin C glucoside. The purification process comprises the following steps: diluting feed liquid obtained by enzymatic reaction into 3 times and thenentering a chromatographic column for chromatography; eluting after the chromatography is ended, transferring eluent to a nano-filtration tank for nano-filtration through a cartridge filter in batches and then sequentially cooling and condensing by a thin film evaporation system and a thin film, transferring the feed liquid to a crystallization tank, carrying out crystallization for three times to obtain a product and drying the product to obtain a finished product. The purification process of the vitamin C glucoside, disclosed by the invention, has high practicality; the obtained product hashigh purity and can fully meet the requirements of customer. 本发明公开了种维生素C葡萄糖苷纯化工艺，经过酶反应得到的料液稀释3倍后进入层析柱层析；层析结束，进行洗脱；将洗脱液分批经保安过滤器转移至纳滤罐纳滤，然后依次经过薄膜蒸发系统和薄膜冷却浓缩，将料液转移至结晶罐进行三次结晶得到产品后干燥得到成品；本发明工艺实用性强，得到的产品纯度高，能充分满足客户需求。