ELUENT SOLUTION

• Main Authors: OCHSENFELD LIANE, SVADBERG ANDERS, EVJE DAG M, HJELSTUEN OLE KRISTIAN, WICKSTROM TORILD
• Format: Patent
• Language: Chinese; English
• Published: 29.06.2018
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; APPARATUS THEREFOR; CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY; CHEMISTRY; COMPOUNDS THEREOF; GENERAL METHODS OF ORGANIC CHEMISTRY; INORGANIC CHEMISTRY; METALLURGY; NON-METALLIC ELEMENTS; ORGANIC CHEMISTRY; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; THEIR RELEVANT APPARATUS; TRANSPORTING

The present invention provides a novel method for the preparation of 18F-fluoride (18F) for use in radiofluorination reactions. The method of the invention finds use especially in the preparation of 18F-labelled positron emission tomography (PET) tracers. The method of the invention is particularly advantageous where bulk solutions are prepared and stored in prefilled vials rather than being freshly prepared on the day of synthesis. Also provided by the present invention is a radiofluorination reaction which comprises the method of the invention, as well as a cassette for use in carrying out the method of the invention and/or the radiofluorination method of the invention on an automated radiosynthesis apparatus. 本发明提供制备用于放射性氟化反应的F-氟离子(F)的新方法。本发明的方法特别是在F-标记的正电子发射断层摄影(PET)示踪剂的制备中得到应用。本发明的方法在制备散装溶液并将其储存在预填充小瓶中而不是在合成当天新鲜制备的情况下特别有利。本发明还提供了放射性氟化反应，其包括本发明的方法，以及用于在自动放射合成设备上进行本发明的方法和/或本发明的放射性氟化方法的盒。