An anti-MRSA naphthalene compound and a preparing method
An anti-MRSA naphthalene compound and a preparing method are disclosed. The molecule formula of the naphthalene compound is C H O4, and the compound is named as naphthalde B. A rice solid fermentation product of a phomopsis sp. strain CGMCC M2017632 is adopted as a raw material of the method, and ex...
Saved in:
Main Authors | , , , , , , |
---|---|
Format | Patent |
Language | Chinese English |
Published |
15.05.2018
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | An anti-MRSA naphthalene compound and a preparing method are disclosed. The molecule formula of the naphthalene compound is C H O4, and the compound is named as naphthalde B. A rice solid fermentation product of a phomopsis sp. strain CGMCC M2017632 is adopted as a raw material of the method, and extract extraction, column chromatography on silica gel, high-performance liquid chromatography,and other steps are performed to obtain the naphthalene compound. A broth microdilution method is adopted to measure activity of the naphthalde B for a staphylococcus aureus standard strain ATCC25923and for a methicillin-resistant staphylococcus aureus standard strain ATCC43300, with MIC being 4 [mu]g/mL and 16 [mu]g/mL respectively. The compound has a simple structure and good activity, canbe adopted as a lead compound of inhibiting methicillin-resistant staphylococcus aureus, and has a good application prospect.
本发明公开了种抗MRSA萘类化合物及其制备方法。所述萘类化合物分子式为CHO,该化合物命名为naphthalde B。其制备方法是以拟茎点霉菌株CGMCC M2017632的大米固体发酵产物为原料,经浸膏提取、硅胶柱层析 |
---|---|
Bibliography: | Application Number: CN201711067146 |