Kit for screening susceptible gene of atrial fibrillation disease

• Main Authors: ZHOU CEFAN, CHEN XINGZHEN, TANG JINGFENG, HUANG YUAN
• Format: Patent
• Language: Chinese; English
• Published: 01.05.2018
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPIRITS; VINEGAR; WINE

The invention discloses a kit for screening susceptible gene of atrial fibrillation disease, and belongs to the technical fields of medicine and molecular biology. The kit comprises the following detection gene: KCNQ1, SCN5A and KCNJ2, and comprises reagents for performing whole exome sequencing on KCNQ1, SCN5A and KCNJ2. By performing whole exome sequencing on KCNQ1, SCN5A and KCNJ2 of a subject,whether the subject carries mutation sites is found, so that the atrial fibrillation disease is determined. The kit screens sporadic atrial fibrillation virulence gene in a crowd, and effectively improves the early detection rate of fibrillation disease, thereby realizing early treatment, reducing the burden of patients, and providing reference for the medication of patients with atrial fibrillation. 本发明公开了种心房颤动疾病易感基因筛查试剂盒，属于医学和分子生物学领域。本发明试剂盒的检测基因为KCNQ1、SCN5A、KCNJ2三个基因，包含用于对KCNQ1、SCN5A、KCNJ2进行全外显子测序的试剂。通过对人KCNQ1、SCN5A、KCNJ2三个基因进行全外显子测序，发现受试者有无携带突变位点，以确定心房颤动疾病。本发明筛选出人群中的散发性心房颤动致病基因，有效提高心房颤动早期检出率，从而做到早期治疗，减轻患者的负担，为房颤患者