Preparation method for fluoromalonic acid diester

• Main Authors: GU JING, DU YOUXING, HE LI, YUAN YUNLONG
• Format: Patent
• Language: Chinese; English
• Published: 20.04.2018
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY

The invention especially relates to a preparation method for fluoromalonic acid diester, belonging to the field of organic synthesis. The preparation method comprises a step of subjecting fluoroacetate and dialkyl carbonate to a condensation reaction in the presence of alkali so as to prepare fluoromalonic acid diester. The preparation method provided by the invention is mild in reaction process;the preparation method has low toxicity and corrosivity due to elimination of conventional chlorination and fluorination steps; and the preparation method does not produce difluoromalonic acid diesterimpurities, has low requirements on factory equipment and is simple and safe to operate. 本发明涉及有机合成领域，特别是涉及种氟代丙二酸二酯的制备方法。本发明提供种氟代丙二酸二酯的制备方法，所述制备方法包括：将氟代乙酸酯与碳酸二烷基酯在碱存在的条件下进行缩合反应，制备获得氟代丙二酸二酯。本发明提供的氟代丙二酸二酯的制备方法反应过程比较温和，因摒弃了常规的氯化氟化步骤，毒性和腐蚀性低，也没有二氟代丙二酸二酯杂质产生，反应对工厂设备要求较低，生产过程操作简单安全。