Small-molecule inhibitor SLD1338 and application thereof in pharmacy

The invention provides a small-molecule inhibitor SLD1338. The structural formula of the small-molecule inhibitor is as shown in the description. The small-molecule inhibitor SLD1338 is applied to preparing a drug for inhibiting spermine oxidase. The result shows that the SLD1338 changes the growth...

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Main Authors SUN LIDAN, WANG YANLIN, CAO CHUNYU, YANG JIANLIN
Format Patent
LanguageChinese
English
Published 06.04.2018
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Abstract The invention provides a small-molecule inhibitor SLD1338. The structural formula of the small-molecule inhibitor is as shown in the description. The small-molecule inhibitor SLD1338 is applied to preparing a drug for inhibiting spermine oxidase. The result shows that the SLD1338 changes the growth cycle of human small cell lung cancer A549 cells and changes the expression content of A549 cyclin,and meanwhile can induce apoptosis of the A549 cells. 本发明提供种小分子抑制剂SLD1338，该小分子抑制剂的结构式为：本发明将所述的小分子抑制剂SLD1338在制备抑制精胺氧化酶的药物上的应用。结果显示SLD1338改变人小细胞肺癌A549细胞生长周期，以及改变A549细胞周期蛋白表达含量，同时可诱导A549细胞发生凋亡。
AbstractList The invention provides a small-molecule inhibitor SLD1338. The structural formula of the small-molecule inhibitor is as shown in the description. The small-molecule inhibitor SLD1338 is applied to preparing a drug for inhibiting spermine oxidase. The result shows that the SLD1338 changes the growth cycle of human small cell lung cancer A549 cells and changes the expression content of A549 cyclin,and meanwhile can induce apoptosis of the A549 cells. 本发明提供种小分子抑制剂SLD1338，该小分子抑制剂的结构式为：本发明将所述的小分子抑制剂SLD1338在制备抑制精胺氧化酶的药物上的应用。结果显示SLD1338改变人小细胞肺癌A549细胞生长周期，以及改变A549细胞周期蛋白表达含量，同时可诱导A549细胞发生凋亡。
Author WANG YANLIN
SUN LIDAN
CAO CHUNYU
YANG JIANLIN
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Snippet The invention provides a small-molecule inhibitor SLD1338. The structural formula of the small-molecule inhibitor is as shown in the description. The...
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SubjectTerms CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Title Small-molecule inhibitor SLD1338 and application thereof in pharmacy
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