METHODS AND COMPOSITIONS RELATED TO GPCR AGONIST POLYPEPTIDES

• Main Authors: LERNER RICHARD A, STURCHLER EMMANUEL, XIE JIA, ZHANG HONGKAI, MC DONALD PATRICIA
• Format: Patent
• Language: Chinese; English
• Published: 27.03.2018
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention provides combinatorial peptide or polypeptide libraries that can become membrane tethered once expressed in cells. The invention additionally provides methods for selecting peptide modulators (e.g., agonists) of GPCRs from the combinatorial libraries of the invention. The invention als...