Novel method for catalytically synthesizing osimertinib intermediate with a graphene/Pd catalyst

• Main Authors: GAO LINGFENG, ZHENG GENGXIU, CUI ZHAOXIN, GU HAIYANG
• Format: Patent
• Language: Chinese; English
• Published: 02.03.2018
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

The invention discloses a novel method for catalytically synthesizing an osimertinib intermediate, [2-[2-dimethylamineethylmethylamine]-4-methoxy-5-benzyloxyamide]phenylamine, with a graphene/Pd catalyst. In the method, an osimertinib intermediate, N-carbobenzoxy-2-methoxy-4-[2-dimethylamineethylmet...