Liposome formulation suitable for treating or preventing tuberculosis
The invention provides liposome formulations comprising fragments from a Mycobacterium tuberculosis-complex strain, it also provides a Mycobacterium tuberculosis-complex strain, fragments of which may be incorporated into selected embodiments of the liposome formulation. The invention further provid...
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Format | Patent |
Language | Chinese English |
Published |
27.10.2017
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Abstract | The invention provides liposome formulations comprising fragments from a Mycobacterium tuberculosis-complex strain, it also provides a Mycobacterium tuberculosis-complex strain, fragments of which may be incorporated into selected embodiments of the liposome formulation. The invention further provides suspensions and pharmaceutical compositions comprising the liposome formulations. Furthermore, it discloses the use of the Iiposome formulations for use in a method of treatment of the human or animal body by therapy, in particular for use in a method of treating or preventing tuberculosis, such as in preventing latent tuberculosis or in tuberculosis prophylaxis, optionally in combination therapy. The formulation of this invention contains sucrose and/or has a lower average particle size than conventional liposome-based agents of tuberculosis therapy, resulting in higher bioavailability and efficiency.
本发明提供了适于治疗或预防结核的脂质体制剂,包含结核分枝杆菌复合群菌株之片段的脂质体制剂,还提供了结核分枝杆菌复合群菌株,其片段可掺入选定的所述脂质体制剂的实施方案中。本发明还提供了包含所述脂质体制剂的悬液和药物组合物。此 |
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AbstractList | The invention provides liposome formulations comprising fragments from a Mycobacterium tuberculosis-complex strain, it also provides a Mycobacterium tuberculosis-complex strain, fragments of which may be incorporated into selected embodiments of the liposome formulation. The invention further provides suspensions and pharmaceutical compositions comprising the liposome formulations. Furthermore, it discloses the use of the Iiposome formulations for use in a method of treatment of the human or animal body by therapy, in particular for use in a method of treating or preventing tuberculosis, such as in preventing latent tuberculosis or in tuberculosis prophylaxis, optionally in combination therapy. The formulation of this invention contains sucrose and/or has a lower average particle size than conventional liposome-based agents of tuberculosis therapy, resulting in higher bioavailability and efficiency.
本发明提供了适于治疗或预防结核的脂质体制剂,包含结核分枝杆菌复合群菌株之片段的脂质体制剂,还提供了结核分枝杆菌复合群菌株,其片段可掺入选定的所述脂质体制剂的实施方案中。本发明还提供了包含所述脂质体制剂的悬液和药物组合物。此 |
Author | AMAT MERCE AMAT ISABEL CARDONA PERE JOAN SELGA ARIADNA REYES BLANCA |
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DocumentTitleAlternate | 适于治疗或预防结核的脂质体制剂 |
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Snippet | The invention provides liposome formulations comprising fragments from a Mycobacterium tuberculosis-complex strain, it also provides a Mycobacterium... |
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Title | Liposome formulation suitable for treating or preventing tuberculosis |
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