Liposome formulation suitable for treating or preventing tuberculosis

• Main Authors: REYES BLANCA, SELGA ARIADNA, CARDONA PERE JOAN, AMAT ISABEL, AMAT MERCE
• Format: Patent
• Language: Chinese; English
• Published: 27.10.2017
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention provides liposome formulations comprising fragments from a Mycobacterium tuberculosis-complex strain, it also provides a Mycobacterium tuberculosis-complex strain, fragments of which may be incorporated into selected embodiments of the liposome formulation. The invention further provides suspensions and pharmaceutical compositions comprising the liposome formulations. Furthermore, it discloses the use of the Iiposome formulations for use in a method of treatment of the human or animal body by therapy, in particular for use in a method of treating or preventing tuberculosis, such as in preventing latent tuberculosis or in tuberculosis prophylaxis, optionally in combination therapy. The formulation of this invention contains sucrose and/or has a lower average particle size than conventional liposome-based agents of tuberculosis therapy, resulting in higher bioavailability and efficiency. 本发明提供了适于治疗或预防结核的脂质体制剂，包含结核分枝杆菌复合群菌株之片段的脂质体制剂，还提供了结核分枝杆菌复合群菌株，其片段可掺入选定的所述脂质体制剂的实施方案中。本发明还提供了包含所述脂质体制剂的悬液和药物组合物。此