Practical processes for producing fluorinated Alpha-ketocarboxylic esters and analogues thereof

• Main Authors: ISHII SHOKO, YAMAZAKI TAKAKO, ISHII AKIHIRO, KASHIWABA TAKASHI, OKAMOTO RYUICHI
• Format: Patent
• Language: Chinese; English
• Published: 13.10.2017
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; APPARATUS THEREFOR; CHEMISTRY; GENERAL METHODS OF ORGANIC CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY

The present invention is capable of producing a fluorinated Alpha-ketocarboxylic ester hydrate by reacting a fluorinated Alpha-hydroxycarboxylic ester with sodium hypochlorite or calcium hypochlorite, the amount thereof being 21 mass% or larger with respect to the composition. Furthermore, by reacting the hydrate with a dehydrating agent, a fluorinated Alpha-ketocarboxylic ester can be produced. By reacting the fluorinated Alpha-ketocarboxylic ester hydrate with a lower alcohol or a trialkyl orthocarboxylate, a fluorinated Alpha-ketocarboxylic ester hemiketal can be produced. Furthermore, by reacting the hemiketal with a dealcoholizing agent, a fluorinated Alpha-ketocarboxylic ester can be produced. 通过使含氟α-羟基羧酸酯与"组成中的质量百分比为21质量％以上的次氯酸钠或次氯酸钙"发生反应，能够制造含氟α-酮羧酸酯水合物。进而，通过使该水合物与脱水剂发生反应，能够制造含氟α-酮羧酸酯。此外，通过使含氟α-酮羧酸酯水合物与低级醇或原羧酸三烷基酯发生反应，能够制造含氟α-酮羧酸酯半缩酮。进而，通过使该半缩酮与脱醇剂发生反应，能够制造含氟α-酮羧酸酯。