A vaccine composition comprising an immunogenic protein and combination adjuvants for use in eliciting antigen-specific t-cell responses

• Main Authors: HSIEH FU-TAN, CHEN KUAN-MING, CHIU YI-TSUI, CHUANG HSIEN-KAI, WU JIUN-MING, LIN YINING, WU CHIA-MAO
• Format: Patent
• Language: Chinese; English
• Published: 13.10.2017
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Vaccine compositions for use in inducing enhanced antigen-specific T cell-mediated immune responses in a subject in need thereof are disclosed. The composition comprises (a) a therapeutically effective amount of an immunogenic protein comprising at least an antigen of a pathogen; (b) a saponin-base adjuvant selected from the group consisting of GPI-0100, Quil A, QS-21; and (c) a Toll-like receptor (TLR) agonist adjuvant selected from the group consisting of monophosphoryl lipid A (MPL), and CpG1826. 本发明提供用以在有此需要的患者中诱发经强化的抗原特异性T细胞介导免疫反应的疫苗组合物。该组合物包含(a)治疗有效量的免疫原性蛋白质，其至少包含病原体的抗原；(b)基于皂苷的佐剂，其选自以下项目所构成群组：GPI-0100、Quil A及QS-21；以及(c)Toll样受体(TLR)激动剂佐剂，其选自以下项目所构成群组：单磷酰脂质A(MPL)及CpG1826。