Pharmaceutical composition, comprising gold compound, for preventing or treating liver fibrosis or liver cirrhosis

• Main Authors: KANG KEON-WOOK, YOON KYUNG-ROK, KIM NA-YOUN
• Format: Patent
• Language: Chinese; English
• Published: 18.08.2017
• Subjects: FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES

The invention relates to pharmaceutical composition, comprising gold compound, for preventing or treating liver fibrosis or liver cirrhosis. The pharmaceutical composition of the present invention can not only promote M2 type transformation of macrophages, but also inhibit the activation of stellate cells due to an increase in TREM-2 expression by containing a gold-containing agent as an active ingredient, and thus can be effectively used for the prevention, pharmaceutical composition for treating or ameliorating hepatic fibrosis or cirrhosis, a food composition, and the like. In addition, gold medicaments such as sinus thiopidate, sodium thioglycolate and glucosinol have long been used to treat different diseases (rheumatoid arthritis), so that they have the advantage of being less likely to cause undesirable effects. 本发明涉及用于预防或治疗肝纤维化或肝硬化的药物组合物，更具体地，涉及用于预防或治疗肝纤维化或肝硬化的药物组合物，其包含含金药剂。本发明的药物组合物通过包含含金药剂作为活性成分，不仅促进巨噬细胞的M2型转化，而且由于TREM-2表达的增加而抑制星状细胞的活化，因此可以有效地用作用于预防、治疗或改善肝纤维化或肝硬化的药物组合物、食品组合物等。此外，含金药剂，例如醋硫葡金、硫代苹果酸金钠和