Preparation method of idebenone
The invention relates to a preparation method of idebenone. The method comprises the following steps: adding an oxidant hydrogen peroxide to coenzyme Q0 and 11-hydroxyundecanoic acid used as raw materials and copper chloride, copper sulfate, copper acetate, silver carbonate, silver oxide, palladium...
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| Main Authors | , , , , |
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| Format | Patent |
| Language | Chinese English |
| Published |
04.08.2017
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| Subjects | |
| Online Access | Get full text |
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| Summary: | The invention relates to a preparation method of idebenone. The method comprises the following steps: adding an oxidant hydrogen peroxide to coenzyme Q0 and 11-hydroxyundecanoic acid used as raw materials and copper chloride, copper sulfate, copper acetate, silver carbonate, silver oxide, palladium chloride or palladium acetate used as a catalyst under the protection of oxygen, and carrying out a free radical alkylation reaction; and carrying out extraction, water washing, drying, reduced pressure distillation and column chromatography on the obtained reaction system to obtain a yellow needle-like crystal 6-(10-hydroxydecyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone, that is idebenone. The preparation method has the advantages of simplicity in operation, low cost and high yield, and is suitable for the large-scale industrial production of idebenone.
本发明涉及种艾地苯醌的制备方法，该方法包括:以辅酶Q0与11-羟基十酸为原料,选择氯化铜、硫酸铜、乙酸铜、碳酸银、氧化银、氯化钯或乙酸钯中的种金属盐作为催化剂,在氧气保护下加氧化剂双氧水,发生自由基烷基化反应。反应体系经萃取、水洗、干燥、减压蒸馏、柱层析,得黄色针状晶体，6-(10-羟基癸基)-2,3-二甲氧基-5-甲基-1， |
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| Bibliography: | Application Number: CN20171388425 |