Pdia4 protein as a target for diagnosis, monitoring and treatment of diabetes

• Main Authors: CHANG LEE-TIAN, YANG WENIN
• Format: Patent
• Language: Chinese; English
• Published: 22.03.2017
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A Pdia4 inhibitor for use in preventing, alleviating and/or treating diabetes and/or diabetes-related complications in a subject in need thereof is disclosed, wherein the Pdia4 inhibitor does not comprise cytopiloyene. A Pdia4 inhibitor and one other anti-diabetic agent for use in combination therapy in preventing, alleviating, treating diabetes and diabetes-related complications, and/or reversing diabetes in a subject in need thereof is also disclosed, wherein the Pdia4 inhibitors for use in combination therapy may comprise cytopiloyene. Also disclosed are methods for diagnosing, treating and monitoring diabetes, and methods of screening for a Pdia4 inhibitor and/or an anti-diabetic agent. 本发明是揭示种Pdia4抑制剂，用于预防、缓解及/或治疗有需求的个体的糖尿病及/或糖尿病相关并发症，其中Pdia4抑制剂不含聚多炔糖苷(cytopiloyene)。本发明亦揭示Pdia4抑制剂及其他抗糖尿病药剂，用于组合疗法，以预防、缓解、治疗有需求的个体的糖尿病及糖尿病相关并发症，及/或逆转糖尿病，其中用于组合疗法的Pdia4抑制剂可包含聚多炔糖苷。本发明亦揭示诊断、治疗及监测糖尿病的方法，以及筛选Pdia4抑制剂及/或抗糖尿病药剂的方法。