Microsphere-based delivery and ex vivo manipulation of dendritic cells for autoimmune therapies

• Main Authors: GIANNOUKAKIS NICK, TRUCCO MASSIMO M
• Format: Patent
• Language: Chinese; English
• Published: 18.01.2017
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to tolerogenic mammalian dendritic cells (iDCs) and methods for the production of tolerogenic DCs. In addition, the present invention provides methods for administration of tolerogenic dendritic cells as well as particles containing oligonucleotides to mammalian subjects. Enhanced tolerogenicity in a host can be useful for treating inflammatory and autoimmune related diseases, such as type 1 diabetes. 本发明涉及致耐受性的哺乳动物树突细胞(iDC)和用于产生致耐受性DC的方法。此外，本发明提供了用于向哺乳动物受试者给予致耐受性树突细胞和包含寡核苷酸的颗粒的方法。宿主中增强的致耐受性可用于治疗炎症和自身免疫相关疾病，例如1型糖尿病。