Preparation method of cefpirome intermediate, namely, 6,7-dihydro-5H-cyclopentane (b) pyridine

• Main Author: LI CHENPU
• Format: Patent
• Language: Chinese; English
• Published: 11.01.2017
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

The invention relates to preparation of a medical intermediate, in particular to a preparation method of a cefpirome intermediate, namely, 6,7-dihydro-5H-cyclopentane (b) pyridine. Cyclopentanone and propargylamine are used as raw materials, a key intermediate, namely, 6,7-dihydro-5H-cyclopentane (b) pyridine of cefpirome is synthesized in an autoclave and an organic solvent by taking a ferric nitrate activated carbon carrier as a catalyst, reaction liquid is filtered and then is adjusted to be alkalescent by using ammonia water, an organic layer is rectified to obtain a product of which the content is 99.0% or more, and the yield reaches 68-72%. The preparation method provided by the invention takes the ferric nitrate activated carbon carrier as the catalyst for high-pressure synthesis, the reaction condition is mild, the reaction time is short, the operation is simple and convenient, the after-treatment is simple, the yield is high, the obtained product contains few impurities, the content is 99.0% or more,