Intensity modulated radiation therapy reverse optimization method based on biomedical equivalent uniform dose constraint

• Main Authors: LAN YIHUA, MIN ZHIFANG, GUO JINLIANG, LI ZHENSHUANG, CHEN XING, SONG XIAO, WANG BAOPING, ZHANG XINGANG, ZHANG KUN
• Format: Patent
• Language: Chinese; English
• Published: 30.11.2016
• Subjects: CALCULATING; COMPUTING; COUNTING; DATA PROCESSING SYSTEMS OR METHODS, SPECIALLY ADAPTED FORADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL, SUPERVISORYOR FORECASTING PURPOSES; PHYSICS; SYSTEMS OR METHODS SPECIALLY ADAPTED FOR ADMINISTRATIVE,COMMERCIAL, FINANCIAL, MANAGERIAL, SUPERVISORY OR FORECASTINGPURPOSES, NOT OTHERWISE PROVIDED FOR

The invention discloses an intensity modulated radiation therapy reverse optimization method based on biomedical equivalent uniform dose constraint. By aiming at a defect of inevitable connection between a conventional equivalent uniform dose mathematical definition inability and actual clinical biomedical description, and by starting from a most frequently used dose volume curve in a biomedical model, a novel equivalent uniform dose mathematical model based on biomedical description is designed, and then an intensity modulated radiation therapy intensity graph constraint optimization mathematical model based on the above mentioned mathematical expression is acquired, a formed non-convex programming mathematical model is used for optimization solution by using a heuristic calculation method. An acquired optimization result is capable of satisfying dosage requirements of clinicians, and is used for personalized customization according to radiation tolerance conditions of cells in different organs of different