Dendritic compound containing 5-aminolevulinic acid hydrochloride and 3-hydroxypyridone, and preparation method and application thereof

• Main Authors: SINAN BETO, ROBERT HEAD, ALEXANDER MACROBERT, ZHOU TAO
• Format: Patent
• Language: Chinese; English
• Published: 09.11.2016
• Subjects: CHEMISTRY; CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS; TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE

A disclosed dendritic compounds containing 5-aminolevulinic acid hydrochloride and 3-hydroxypyrid-4-one possess the general structural formula described in the specification, and in the general formula, m>=3 and n>=1. The invention also discloses a preparation method and application of the above dendritic compounds. The compounds are applicable to prepare photodynamic therapy medicaments for treating diseases such as basal cell carcinoma, squamous cell carcinoma, skin carcinoma, lung carcinoma, condyloma acuminatum, breast carcinoma and oral epidermoid carcinoma. 本发明公开了种含有5-氨基酮戊酸和3-羟基吡啶-4-酮的树形化合物，其具有如下结构通式：通式中m≥3，n≥1。本发明还同时公开了上述树形化合物的制备方法及用途：可用于制备光动力学治疗药物，例如用于制备治疗基底细胞癌、鳞状细胞癌、皮肤癌、肺癌、尖锐湿疣、乳腺癌、口腔表皮样癌的光动力学治疗药物。