SITE-DIRECTED MODIFICATION OF FVIII

• Main Authors: STRAUSS JONATHAN S, TJANDRA HENDRI, BARNETT THOMAS, MEI BAISONG, WANG DEQIAN, CHEN JLANMIN, MURPHY JOHN E, PAN CLARK Q, TANG LIANG
• Format: Patent
• Language: Chinese; English
• Published: 13.07.2016
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

This invention relates to Factor VIII muteins that are covalently bound, at a predefined site that is not an N-terminal amine, to one or more biocompatible polymers such as polyethylene glycol. The mutein conjugates retain FVIII procoagulant activity and have improved pharmacokinetic properties. 本发明...