Processes for preparing jak inhibitors and related intermediate compounds

• Main Authors: XIA MICHAEL, LIU PINGLI, LIN QIYAN, LI MEI, METCALF BRIAN W, MELONI DAVID, PAN YONGCHUN, YUE TAI-YUEN, ZHOU JIACHENG, WANG HAISHENG, RODGERS JAMES D
• Format: Patent
• Language: Chinese; English
• Published: 15.06.2016
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

The present invention is related to processes for preparing chiral substituted pyrazolyl pyrrolo[2,3-di]pyrimidines of Formula III, and related synthetic intermediate compounds. The chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines are useful as inhibitors of the Janus Kinase family of protein tyrosine kinases (JAKs) for treatment of inflammatory diseases, myeloproliferative disorders, and other diseases. 本发明涉及制备式III手性取代的吡唑基吡咯并[2，3-d]嘧啶及相关合成中间化合物的方法。该手性取代的吡唑基吡咯并[2，3-d]嘧啶可作为蛋白质酪氨酸激酶的Janus激酶族(JAK)的抑制剂，用于治疗炎性疾病、骨髓增生病症及其它疾病。