Synthesizing method of voriconazole copper acetate complex with anti-bacterial activity

• Main Authors: ZHAO YANMING, TANG GUIMEI, WANG YONGTAO, WAN WENZHU
• Format: Patent
• Language: Chinese; English
• Published: 30.03.2016
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention provides a synthesizing method of a voriconazole copper acetate complex with anti-bacterial activity. The synthesizing method comprises the following steps of dissolving voriconazole (FZ) and copper acetate into a certain amount of water and organic solvent; then, transferring a reaction mixture into a flask, heating, lowering the temperature to the room temperature, filtering, stilling, separating a deep blue blocky target product, and using single-crystal X-rays to determine a crystal structure (refer to figure 1). A chemical formula is [Cu2(FZ)2(CH3COO)2(H2O)].2H2O, and the complex is absorbed by ultraviolet rays at 205nm and 255nm. Compared with the infrared spectrum of a ligand, the infrared spectrum of the complex 1 shows that a C-N bond of the complex 1 extends, shrinks, vibrates and moves with 10cm<-1>. The synthesizing method has the advantages that the experiment result shows that the complex has stronger anti-bacterial activity on achromobacter xylosoxidans, bacillus subtilis, candida