Fluorescent solid lipid nanoparticles composition and preparation thereof
The present invention discloses a solid lipid nanoparticle (SLN) comprising: a) a solid lipid core comprising at least a glyceride and/or at least a fatty acid; b) a mixture of amphiphilic components forming a shell around said core a); c) an alkaline-earth complex with a compound of formula I and/o...
Saved in:
| Main Authors | , , , |
|---|---|
| Format | Patent |
| Language | Chinese English |
| Published |
02.03.2016
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | The present invention discloses a solid lipid nanoparticle (SLN) comprising: a) a solid lipid core comprising at least a glyceride and/or at least a fatty acid; b) a mixture of amphiphilic components forming a shell around said core a); c) an alkaline-earth complex with a compound of formula I and/or II: d) at least a fluorescent dye selected from: a cyanine fluorescent dye and /or a polyetherocyclic compound selected from: coumarin, pyrano, quinoline, pyranoquinoline, indole and pyranoindole derivates in acid form or a pharmaceutically acceptable salt thereof. These nanoparticles allow a prolonged blood circulation half-life, show enhanced photostability and improved fluorescence signal. The dye is preserved from degradation and improves the fluorescent quantum yield. |
|---|---|
| AbstractList | The present invention discloses a solid lipid nanoparticle (SLN) comprising: a) a solid lipid core comprising at least a glyceride and/or at least a fatty acid; b) a mixture of amphiphilic components forming a shell around said core a); c) an alkaline-earth complex with a compound of formula I and/or II: d) at least a fluorescent dye selected from: a cyanine fluorescent dye and /or a polyetherocyclic compound selected from: coumarin, pyrano, quinoline, pyranoquinoline, indole and pyranoindole derivates in acid form or a pharmaceutically acceptable salt thereof. These nanoparticles allow a prolonged blood circulation half-life, show enhanced photostability and improved fluorescence signal. The dye is preserved from degradation and improves the fluorescent quantum yield. |
| Author | MAIOCCHI ALESSANDRO GHIANI SIMONA MIRAGOLI LUIGI CAMINITI LARA |
| Author_xml | – fullname: MIRAGOLI LUIGI – fullname: MAIOCCHI ALESSANDRO – fullname: CAMINITI LARA – fullname: GHIANI SIMONA |
| BookMark | eNrjYmDJy89L5WTwdMspzS9KLU5OzStRKM7PyUxRyMksAJJ5iXn5BYlFJZnJOanFCsn5uQX5xZklmfl5Col5KQoFRalAyUQwvyQjtSg1P42HgTUtMac4lRdKczMourmGOHvophbkx6cWFyQCrUgtiXf2MzQwNTY3NzawdDQmRg0AhPo3dw |
| ContentType | Patent |
| DBID | EVB |
| DatabaseName | esp@cenet |
| DatabaseTitleList | |
| Database_xml | – sequence: 1 dbid: EVB name: esp@cenet url: http://worldwide.espacenet.com/singleLineSearch?locale=en_EP sourceTypes: Open Access Repository |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Chemistry Sciences |
| ExternalDocumentID | CN105377309A |
| GroupedDBID | EVB |
| ID | FETCH-epo_espacenet_CN105377309A3 |
| IEDL.DBID | EVB |
| IngestDate | Fri Jul 19 15:46:38 EDT 2024 |
| IsOpenAccess | true |
| IsPeerReviewed | false |
| IsScholarly | false |
| Language | Chinese English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-epo_espacenet_CN105377309A3 |
| Notes | Application Number: CN201480037003 |
| OpenAccessLink | https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20160302&DB=EPODOC&CC=CN&NR=105377309A |
| ParticipantIDs | epo_espacenet_CN105377309A |
| PublicationCentury | 2000 |
| PublicationDate | 20160302 |
| PublicationDateYYYYMMDD | 2016-03-02 |
| PublicationDate_xml | – month: 03 year: 2016 text: 20160302 day: 02 |
| PublicationDecade | 2010 |
| PublicationYear | 2016 |
| RelatedCompanies | BRACCO IMAGING S.P.A |
| RelatedCompanies_xml | – name: BRACCO IMAGING S.P.A |
| Score | 3.1405213 |
| Snippet | The present invention discloses a solid lipid nanoparticle (SLN) comprising: a) a solid lipid core comprising at least a glyceride and/or at least a fatty... |
| SourceID | epo |
| SourceType | Open Access Repository |
| SubjectTerms | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| Title | Fluorescent solid lipid nanoparticles composition and preparation thereof |
| URI | https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20160302&DB=EPODOC&locale=&CC=CN&NR=105377309A |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3dS8MwED_mFPVNp6LzgwrSt2LXbx-KuLRlCuuGTNnb6EfCKiMtXYfgX-8165wv-hLyASEcudxd8rtfAO5UplNHS1MldqiuGLaTKDFaWoWpUWL0UNMtQaU0DK3Bm_EyNact-Njkwgie0E9BjogalaC-V-K8LraXWJ7AVi7v4wy78sdg4npyEx3Xfyarmuz1XX888kZEJsQloRy-oq9r6jbu5oenHdhFN9qu4V_-e7_OSil-m5TgCPbGOBuvjqH1Ne_AAdn8vNaB_WHz4I3VRveWJ_AcLFZ5uWZfknDHZKm0yAosecQx8m0AblKNEW-AWFLEU6ko6ZreG9u1s0dzdgq3gT8hAwXXNPsRwIyE2-XrZ9DmOafnIDHLttTEwYDLTo2eGjupzhgzaRSrdhJR6wK6f8_T_W_wEg5rYQqslXYF7apc0Ws0vlV8I6T2Dd14i0M |
| link.rule.ids | 230,309,783,888,25578,76884 |
| linkProvider | European Patent Office |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1LS8NAEB5qFetNq1LrK4LkFkzz9lDEbhpabdIiUXoLeexipSShTRH89U62qfWil2UfsCzDzs7M7jffAtzKTKWWkiRSZFFV0kwrliK0tBKTw1jroKYbnErJ9YzBq_Y01ac1-NjkwnCe0E9OjogaFaO-F_y8zreXWDbHVi7vohl2ZQ-O37XFKjou_0yWFdHudfuTsT0mIiFd4oneC_q6umribr5_3IFddLGtkme__9Yrs1Ly3ybFOYS9Cc6WFkdQ-3pvQoNsfl5rwr5bPXhjtdK95TEMnfkqW6zZlwTcMbNEmM9yLNMwxci3ArgJJUa8AmIJYZoI-YKu6b2xXTp7NGMncOP0fTKQcE3BjwAC4m2Xr55CPc1S2gKBGaYhxxYGXGaideTISlTGmE7DSDbjkBpn0P57nvZ_g9fQGPjuKBgNvedzOCgFy3FXygXUi8WKXqIhLqIrLsFvjbeOMw |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Apatent&rft.title=Fluorescent+solid+lipid+nanoparticles+composition+and+preparation+thereof&rft.inventor=MIRAGOLI+LUIGI&rft.inventor=MAIOCCHI+ALESSANDRO&rft.inventor=CAMINITI+LARA&rft.inventor=GHIANI+SIMONA&rft.date=2016-03-02&rft.externalDBID=A&rft.externalDocID=CN105377309A |